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Public release date: 02 December 2009
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Erectile dysfunction as a predictor for subsequent atherosclerotic cardiovascular events
In spite of the high interest regarding
erectile dysfunction questions (ED)
and cardiovascular diseases (CV), there is little published information on the role of ED as a predictor
for subsequent CV events.
A recent study at Keogh Institute for Medical Research, Perth, Australia, aimed to investigate the role
of ED as a predictor for atherosclerotic cardiovascular events subsequent to the manifestation of erectile dysfunction.
The investigation involved the retrospective study of
sexual health data in men with erectile dysfunction
linked to hospital morbidity data and death registrations. By using the linked data, the incidence rates of
atherosclerotic CV events subsequent to the manifestation of ED were estimated in men with ED and no
atherosclerotic CV disease reported prior to the manifestation of erectile dysfunction. The risk of subsequent atherosclerotic
CV events in men with ED was assessed by comparing these incidence rates with those in the general male population.
Standardized incidence rate ratio (SIRR), comparing the incidence of atherosclerotic CV events subsequent to the
manifestation of ED in a cohort of 1,660 men with ED to the incidence in the general male population.
On the basis of hospital admissions and death registrations,
men with erectile dysfunction had a statistically
significantly higher incidence of atherosclerotic CV events.
There were significantly increased incidence rate ratios in all age groups younger than 70 years, with a statistically
highly significant downward trend with increase of age (P < 0.0001) across these age groups. Younger age at first
manifestation of ED, cigarette smoking, presence of comorbidities and socioeconomic disadvantage were all
associated with higher hazard ratios for subsequent atherosclerotic cardiovascular events.
The findings show that erectile dysfunction and week erections in men
are not only significantly associated with but is also strongly predictive of subsequent atherosclerotic CV events.
This is even more striking when erectile dysfunction presents at a younger age.
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