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Public release date: 18 June 2008
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Low testosterone appears to increase long-term risk of death
Men may not live as long if they have low testosterone, regardless of their age, according to a new study.
The results will be presented at The Endocrine Society's 90th Annual Meeting in San Francisco.
The new study, from Germany, adds to the scientific evidence linking deficiency of this sex hormone with increased
death from all causes over time—so-called "all-cause mortality."
The results should serve as a risk warning for males with low testosterone to have a healthier lifestyle, including weight
control, regular exercise and a healthy diet, said lead author Robin Haring, a PhD student from Ernst-Moritz-Arndt
University of Greifswald, Institute for Community Medicine.
"It is very possible that lifestyle determines levels of testosterone," he said.
In the study, Haring and co-workers looked at death from any cause in nearly 2,000 men aged 20 to 79 years who were
living in northeast Germany and who participated in the Study of Health in Pomerania (SHIP). Follow-up averaged 7 years.
At the beginning of the study, 5 percent of these subjects had low blood testosterone levels, defined as the lower end of
the normal range for young adult men. The men with low testosterone were older, more obese, and had a greater prevalence and risk
of diabetes and high blood pressure, compared with men who had higher testosterone levels, Haring said.
Men with low testosterone levels had more than 2.5 times greater risk of dying during the next 10 years compared to men
not having low testosterone, the study found. This difference was not explained by age, smoking, alcohol intake, level of
physical activity, or increased waist circumference (a risk factor for diabetes and heart disease), Haring said.
In cause-specific death analyses, low testosterone predicted increased risk of death due to cardiovascular disease and
cancer but not death of any other single cause.
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DPC Biermann, Bad Nauheim, Germany, provided the testosterone reagent, and Novo Nordisc provided partial funding for
this analysis. Founded in 1916, The Endocrine Society is the world's oldest, largest, and most active organization devoted to research
on hormones, and the clinical practice of endocrinology. Today, The Endocrine Society's membership consists of over 14,
000 scientists, physicians, educators, nurses and students in more than 80 countries. Together, these members represent
all basic, applied, and clinical interests in endocrinology. The Endocrine Society is based in Chevy Chase, Maryland.
To learn more about the Society, and the field of endocrinology, visit our web site at
www.endo-society.org
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