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Public release date: 05 February 2010
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Non-invasive MR Spectroscopy to determine ability to be fathers

According to a new study related to men sexual health that was published in Human Reproduction, men with no sperm in their ejaculate - a condition known as azoospermia - may no longer need invasive procedures to determine if they have sperm in their testes.

The study concluded that a simple metabolic scan that combines the use of H Spectroscopy with magnetic resonance imaging (MRI) n-known as MR Spectroscopy - can be used to determine the likelihood of finding sperm in men with non-obstructive azoospermia (NOA).

There are traditional methods for evaluating existence of sperm, such as testicular biopsy and microdissection, but thy are considered highly invasive and have only a 60 percent to 65 percent success rate. FNA Sperm Mapping, pioneered by Dr. Turek, is far less invasive, but still involves the use of fine needle aspiration to obtain tissue samples from the testes.

In contrast, MR Spectroscopy, or magnetic resonance spectroscopic imaging, is a non-invasive scan that measures metabolic activity in the testis. MR Spectroscopy is a non-invasive diagnostic technology that is cleared by the FDA. The study shows that the scan is as accurate as a more invasive testis biopsy in reading several abnormal patterns of sperm production typically associated with infertility and azoospermia. It also shows that testis tissue containing spermatids or sperm carry a distinct chemical signature that can be distinguished by MR Spectroscopy.

Additionally, MR Spectroscopy has the ability to evaluate testis metabolism in as many as 100 areas within the testis, significantly increasing the ability to sample for sperm well beyond any of the more invasive techniques commonly used today.



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