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Public release date: 11 January 2010
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Race and obesity affect outcomes among diabetics following prostatectomy
According to research from Duke University Medical Center appearing in Cancer Epidemiology, Biomarkers & Prevention,
those obese white men having both diabetes
and prostate cancer have significantly worse
outcomes following radical prostatectomy
than do men without diabetes who undergo the same procedure
Previous studies have shown that diabetes is linked with a lower risk of developing prostate cancer,
at least in white men. However, the impact of diabetes on outcomes after prostate cancer surgery
has not been as clear.
The new research found that diabetes was significantly associated with more aggressive disease in obese white men and
less aggressive disease for all other subsets of men in the study.
Studies have shown that
Black men are significantly more likely than white
men to develop prostate cancer, to have more aggressive disease
and to experience a greater likelihood of recurrence.
Diabetes is more prevalent among black adults than white adults (11.8 per cent vs. 7.5 percent, respectively).
Obesity is also associated with increased risk of aggressive disease, recurrence, and
prostate cancer mortality in overweight men – and diabetes.
Given that race and obesity are related to both aggressive prostate cancer and diabetes, the study authors hypothesized
that the association between diabetes and prostate cancer progression might vary by race and obesity.
The study found no link between diabetes and prostate cancer progression. But in a secondary analysis, after sorting
the data by race and weight, investigators found an association between diabetes and an increased risk of recurrence
and a trend toward more aggressive recurrence (reflected in a shorter doubling time of the PSA) -- but only among obese
white men. In all other subgroups, diabetes was associated with lower recurrence risk and longer PSADT.
The study findings are published in Cancer Epidemiology, Biomarkers & Prevention
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