Do you have questions men's health related?
Please send them!
If you have a question related to men's health, please fill the form bellow.
1. It is a must to provide a valid email, unless you want your questions to be ignored.
We won't make your email public, but we like to talk with live persons.
2. To protect
your identity, take care the name you fill. We make public your name exactly as it is.
|
Public release date: 01 September 2008
[
]
Sex hormones make men more prone to heart disease
According to a new study at University of Leicester, men are more prone to - and likely to
die of - heart disease compared with women of a similar age - and sex hormones are to blame.
The findings of a study by Dr Maciej Tomaszewski, New Blood Lecturer in Cardiovascular Medicine in the Department of Cardiovascular Sciences at the University of Leicester, suggest that this "male disadvantage" may be related to the sex-specific effects of naturally occurring sex hormones.
The research by Dr Tomaszewski and his colleagues, looked at ways that the sex hormones - estradiol, estrone, testosterone and androstenedione - interacted with three major risk factors of heart disease (cholesterol, blood pressure and weight).
They found that two of these sex hormones (estradiol and estrone, called together estrogens) are linked to increased levels of bad cholesterol (LDL-cholesterol) and low levels of good cholesterol (HDL-cholesterol) in men.
This suggests that certain sex hormones may be important risk factors of
heart disease in men, even before they present symptoms of coronary artery disease or stroke.
Dr Tomaszewski commented: "We hypothesised that circulating concentrations of sex hormones were associated with cardiovascular disease risk factors in men long before any apparent manifestations of cardiovascular disease such as stroke or myocardial infarction".
"Our studies showed that one of the sex hormones - estradiol - was associated positively with total cholesterol and negatively with HDL-cholesterol. Circulating concentrations of another sex hormone - estrone - showed strong positive associations with both total cholesterol and LDL-cholesterol.
"Thus, men with the highest concentrations of estrone and estradiol may have the highest level of cardiovascular
risk as their levels of detrimental LDL-cholesterol are high whilst their cardio-protective HDL-cholesterol is low.
"Most importantly, the demonstrated associations between cholesterol and estrogens were independent of other sex hormones (testosterone and androstenedione), age, body weight, blood pressure and other potential confounding factors.
"Our data suggest that higher levels of estrogens may have negative influence on lipid profile in men early in life, before the apparent onset of cardiovascular disease.
"Why natural endogenous estrogens that are generally seen as cardio-protective in women increase cardiovascular risk in men remains to be elucidated. Future prospective studies are needed to confirm that higher levels of endogenous estrogens in youth increase the risk of heart disease later in man's life.
"A number of other investigations on sex-specific aspects of cardiovascular disease are in progress in our Department and I am sure that we will be able to continue providing information in this area of research in the future."
# # #
http://www.le.ac.uk/
|
|
