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Public release date: 31 January 2008
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Sex hormones unrelated to prostate cancer risk
Sex hormones circulating in the blood do not appear to be associated with prostate cancer risk,
according to data from 18 prior studies.
Having high levels of male sex hormones, known as androgens, has long been hypothesized as a risk factor
for prostate cancer. Nearly two dozen prospective studies have examined the relationship between
circulating sex hormones and prostate cancer risk, but the results have been inconsistent.
Andrew Roddam, D.Phil., of the University of Oxford in England and colleagues at the Endogenous Hormones
and Prostate Cancer Collaborative Group collected the original data from 18 studies and analyzed it to
determine the relationship between blood levels of sex hormones and prostate cancer. The pooled data
included 3,886 men with prostate cancer and 6,438 controls.
The researchers found no association between prostate cancer risk and blood levels of different forms of
testosterone or estrogen.
"The results of this collaborative analysis of the existing worldwide data on the associations between
endogenous hormone concentrations and prostate cancer risk indicate that circulating concentrations of
androgens and [estrogens] do not appear to be associated with the risk of prostate cancer," the authors write.
In an accompanying editorial, Paul Godley, M.D., Ph.D., and colleagues at the University of North Carolina
at Chapel Hill commend the authors for collaborating on this analysis, and they encourage researchers to
use the results as an opportunity to shift the focus of prostate cancer research.
"The study obliges the scientific community to move past a seductive, clinically relevant, and biologically
plausible hypothesis and get on with the difficult task of exploring, analyzing, and characterizing
modifiable risk factors for prostate cancer," the editorialists write.
Article: Endogenous Hormones and Prostate Cancer Collaborative Group. Endogenous Sex Hormones and Prostate
Cancer: A Collaborative Analysis of 18 Prospective Studies. J Natl Cancer Inst 2008; 100: 170-183
Editorial: Carpenter WR, Robinson WR, Godley PA. Getting Over Testosterone: Postulating a Fresh Start for
Etiologic Studies of Prostate Cancer. J Natl Cancer Inst 2008; 100:158-159
Adapted from materials provided by Journal of the National Cancer Institute, via EurekAlert!, a service of AAAS.
Source: ScienceDaily. Retrieved January 31, 2008, from
http://www.sciencedaily.com/releases/2008/01/080129160824.htm
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