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Public release date: 23 August 2008
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Study reveals prostate cancer risk increased in obese men
According to findings of a new study at the Fred Hutchinson Cancer Research Center in Seattle, use of cholesterol-lowering
statin drugs, especially long-term use, appears to raise the risk of prostate cancer among obese men. No overall
association was found between the risk of prostate cancer and the current or past use of statin treatment. Duration of
statin use was also not associated with prostate cancer risk.
Dr. Janet L. Stanford, the team leader, and colleagues wrote in the American Journal of Epidemiology that "Given the
epidemic of obesity in the U.S. and the frequent use of statins, the positive association we observed raises substantial
concern as to the safety of these widely prescribed agents"
To have this conclusion the researchers matched 1,001 men with prostate cancer diagnosed between 2002 and 2005 with 942
age-matched cancer-free controls from King County, Washington.
Researchers found no evidence that use of a statin was associated with risk of developing more aggressive subtypes of
prostate cancer. At the same time they found no support for the current hypothesis that statin use may reduce risk of
prostate cancer. However, the conclusions do suggest a significant increase in the risk of developing prostate cancer
associated with current statin use and with longer durations of use among obese men (obesity defined as a body mass index of
30 greater).
According to research team, among obese men current use of a statin was associated with a 50 percent increase in risk
of prostate cancer; and use for 5 or more years was associated with an 80 percent increase in risk of the disease; both
of these risk estimates were statistically significant, but these findings warrant further investigation.
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