A scientific team at SLU in Uppsala Sweden and University of Cambridge has discovered a molecule that can prevent a toxic protein involved Alzheimer’s disease from building up in the brain.
The new molecule - designed by scientists in Sweden - is a small protein known as an Affibody (an engineered binding protein). In this new study, researchers at the University of Cambridge and the Swedish University of Agricultural Sciences found that in test-tube experiments this protein binds to the A-beta peptide, preventing it from forming clumps and breaking up any clumps already present.
Researchers found that in test tube studies the molecule not only prevents the protein from forming clumps but can also reverse this process. Then, using fruit flies with Alzheimer’s disease, they showed that the same molecule effectively “cures” the insects of the disease.
The research will continue in collaboration with KTH and the biotech enterprise Affibody AB, Stockholm. The study is published in PLoS Biology.

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