According to experts, small interfering RNA (siRNA), a type of genetic material, can block potentially harmful activity in cells, such as tumor cell growth. The problem is that delivering siRNA to specific cells, other cells have been affected.
Researchers at University of Iowa have modified siRNA so that it can be injected into the bloodstream and impact targeted cells while producing fewer side effects. The findings, which were based on animal models of prostate cancer, also could make it easier to create large amounts of targeted therapeutic siRNAs for treating cancer and other diseases.
The study results appeared online Aug. 23 in the journal Nature Biotechnology.
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