The growth of the prostate gland depends on circulating androgens and intracellular steroid signalling pathways. The effects of androgens are mediated through the androgen receptor (AR), a nuclear transcription factor encoded by the AR gene. The common polymorphisms, CAG and GGN repeats, in exon 1 of this gene have been implicated as possible risk factors.
Variation […]

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A new study at Harvard Medical School reveals that illicit use of HGH (human growth hormone) has become common among young American male weightlifters. Additionally, illicit HGH use in this population is often associated with polysubstance abuse involving both performance-enhancing and classical drugs.
HGH, once an expensive performance-enhancing drug used exclusively by elite athletes, has become […]

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Male hypogonadism is commonly diagnosed on the basis of subphysiological concentrations of androgen hormones, and is associated with many symptoms present in advanced cancer. Androgen deficiency might be an important cause of muscle wasting in both cancer cachexia and sarcopenia.
We found no definitive association between nutritional, functional, or quality-of-life characteristics and male hypogonadism. Possible associations […]

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Male menopause is also called “andropause” or late-onset hypogonadism. British researchers from Imperial College London and the University of Manchester described a set of concrete symptoms for “male menopause” for the first time. They have also determined that only about 2 percent of men aged 40 to 80 suffer from the condition, far less than previously thought.
The […]

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Gender-specific behavior patterns are often chalked up to testosterone in men and estrogen in women. However, how these two hormones interact to control masculinization of the brain and behavior remained to be established.
A new study at the University of California, San Francisco, explains why the hormone issue isn’t so clear cut. The male hormone testosterone […]

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Administration of androgens supplements has been advocated for men with sexual dysfunction and hypoandrogenism. The preponderance of evidence indicates that most delivery forms of testosterone are effective but the role of dehydroepiandrosterone is controversial. Recently Queen’s University, Kingston, Ontario, Canada, conducted a placebo-controlled, randomized trial of oral androgen (testosterone versus dehydroepiandrosterone) supplementation was carried out […]

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Researchers from Boston University School of Medicine believe that androgen deficiency might be the underlying cause for a variety of common clinical conditions, including diabetes, erectile dysfunction, metabolic syndrome and cardiovascular disease.
Androgens, such as testosterone, are a steroid hormone that supports the development and maintenance of male characteristics. In a number of studies, androgen deficiency […]

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Australian company, Acrux, today announced positive results from a Phase III trial evaluating the safety and efficacy of Axiron in 155 men with testosterone deficiency (hypogonadism).
Axiron is applied to the underarm using a unique “no-touch” applicator. Subjects were permitted to use an underarm deodorant or antiperspirant during the trial. More than half of the men […]

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Testosterone is a hormone made in the testes that helps men to maintain male characteristics.
Some claims have been made that testosterone can raise muscle mass, sharpen memory, boost sex drive and improve energy. But none of these are proven.
One study shows testosterone replacement in men with angina or chronic heart failure raises their exercise tolerance. […]

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Contrary to predictions, males of high genetic quality are not very successful when it comes to fertilizing eggs. A new study on seed beetles at the Department of Ecology and Evolution, Uppsala University, Sweden, in cooperation with the Department of Biological Sciences, University of Aarhus, Denmark, shows that, contrary to predictions, males of low genetic […]

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