Heart Failure Drugs Linked to Hip Bone Loss in Older Men

Loop diuretics more than double risk for fractures, study finds. E-mail this article

A U.S. study suggests loop diuretics, drugs commonly prescribed to treat heart failure and hypertension, increase the risk of hip bone loss in older men.

The researchers noted that loop diuretics are one of the most commonly prescribed medications among older adults. These drugs increase the amount of calcium excreted in urine, and long-term use may harm bones. Previous observational studies have found an association between the use of loop diuretics and increased risk of fractures.

But the researchers said there’s been “uncertainty as to whether this increased fracture risk is attributable to negative effects on bone mineral density, fall-related mechanisms (e.g., dizziness and orthostatis [low blood pressure when standing up]), or associated comorbidities (co-occurring illnesses).”

The study was published in the April 14 issue of the Archives of Internal Medicine.