Heavy workload ups risk of fatal heart disease in unfit men

A sientific team from the Bispebjerg University Hospital, Copenhagen, suggests that in case of physically unfit men, high physical work demands are linked to an increased risk of death from ischemic heart disease (IHD).

Researchers conclude that the increase in risk is not explained by the higher rates of heavy work and health risk factors among men at lower socioeconomic levels.The finding is especially important because many men are now being treated with new, highly potent androgen suppression therapy, which these researchers believe will significantly increase the risk of future development of neuroendocrine tumors. Androgen is the fuel that feeds adenocarcinoma prostate cancers — the most common kind of prostate cancer — and androgen suppression therapy effectively destroys cancer cells that depend on this hormone. But the treatment does not touch neuroendocrine cells that may have been part of the tumor mix, and those untreatable cells now have room to grow and spread, the researchers say.