A researcher at the Oregon Health & Science University Cancer Institute has identified a protein, known as CRP and produced by liver, that is a strong indicator of survival for men with advanced prostate cancer.
Because CRP is elevated in the presence of inflammation, a simple blood test that is already available could help in clinical decision making and patient counseling.
The research also suggests that inflammation may play an important role in driving prostate cancer progression and resistance to therapy.
Inflammatory cells are attracted to cancer sites and this local inflammation can lead to a release of inflammatory markers, like CRP.
Because this is the first time CRP has been linked with both response and survival in study subjects with advanced prostate cancer receiving chemotherapy, it will be important to confirm this finding in an independent data set before this can become a routine blood test for men with advanced prostate cancer, Beer explained.
The study is published online in the journal Cancer.
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