A new study at the University of Rochester Medical Center concluded that the regular use of nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen, may reduce serum levels of the prostate biomarker, PSA (prostate specific antigen), and hence may alter the detection of prostate cancer in individuals who take these medications.
The investigators determined PSA levels in 1,319 men over the age of 40 years who participated in the 2001-2002 National Health and Nutrition Examination Survey.
Chronic inflammation has been linked to many different types of malignancies, including prostate cancer. Researchers suspect that inflammation associated with prostate cancer may occur through a variety of mechanisms such as infection, hormonal changes, physical trauma, urine reflux, and dietary habits. Studies have shown that cyclooxygenase (COX) enzymes, which are inhibited by NSAIDs, play an important role in inflammation. In addition, several reviews have indicated that NSAID use is associated with a lower incidence of prostate cancer.
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