Using the expression patterns of various genes, US researchers have created a model that can predict systemic progression or death due to prostate cancer in men with high-risk disease who have undergone radical prostatectomy.
As reported in the August 20th issue of the Journal of Clinical Oncology, the researchers analyzed gene expression data from 102 prostate tissue samples. Candidate genes were those that were overexpressed in tumor samples compared to normal tissue and those that showed higher expression in Gleason patterns 4 and 5 than in 3.
Examination of the candidate genes and creation of the predictive model was done in case-control study of 157 high-risk patients. The model was then validated in a separate case-control study of 57 patients.
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