According to a new study published online July 28 in the Journal of the National Cancer Institute, MEK4 has been identified as a pro-invasion protein and the target for genistein, a dietary compound, in prostate cancer cells.
A research team at Department of Medicine at Northwestern University in Chicago, investigated the target for genistein in prostate cancer cells by assessing cell invasion and gene and protein expression of mitogen-activated protein kinase 4 (MEK4) and matrix metalloproteinase-2 (MMP-2), which is associated with cell invasion.
Computer modeling showed that genistein could bind to the active site of MEK4, and an enzymatic assay showed that genistein inhibited MEK4 kinase activity. The MMP-2 transcript level was statistically significantly higher in normal prostate epithelial cells, which are target cells for chemoprevention, from untreated patients with prostate cancer than from genistein-treated patients.
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