Over-expression of Stat5 protein leads to deadly spread of prostate cancer

A study at the Kimmel Cancer Center at Jefferson has found that Stat5, a signaling protein previously found to be key to survival of prostate cancer, is also involved in metastasis.

Researchers demonstrate in both laboratory and animal models that nuclear Stat5 over-expression leads to a deadly spread of the cancer. They add that their work with mice was unique in that it was the first time Stat5 was associated with prostate cancer metastasis processes in an animal model.

Study findings are reported in the online edition of Endocrine-Related Cancer.