A study carried by team of Keio University (Japan) researchers and carrying the optimal routes for transplanting neural stem/progenitor cells (NS/PCs) in animal models of spinal cord injury (SCI) has demonstrated that intralesional (IL) injection conferred benefits over intravenous injection (IV) and intrathecal (IT) injection.For their study, the researchers used a new reporter gene, called “ffLuc,” a novel fusion protein, for bioluminesence (BLI) imaging in order to track the transplanted cells via MRI from injection site to spinal cord lesion. As MRI signals from dead cells cannot be distinguished from those of living cells, to overcome this difficulty, researchers used a BLI system that tracked only living cells.
The team leader summarized that taken together, the study findings indicate that the best method for transplanting NS/PCs into the spinal cord injury site is by intralesional injection.
The study has been published in Cell Transplantation
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