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Public release date: 13 March 2009
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Bone marrow stem cell injections may help cure spinal cord injury
Scientific team from DaVinci Biosciences, Costa Mesa, California, and Hospital Luis Vernaza in Ecuador reveals that injecting a patient's own bone marrow-derived stem cells into the spinal column using multiple routes can be an effective treatment for spinal cord injury (SCI).
Revealing their findings in the journal Cell Transplantation, the researchers said that they administered bone marrow-derived stem cells (BMCs) directly into the spinal column, spinal canal and intravenously to eight patients with SCI-four acute and four chronic.
They say that such a treatment can return some quality of life for SCI patients without serious adverse events.
The corresponding author Dr. Francisco Silva revealed that several functional improvements, most importantly improved bladder control, were observed in the eight patients who received BMC transplants through various routes, and were followed for two years.
Researchers also observed that one of their cases suffered a gunshot wound, and that their study marked the first time a gunshot wound victim had received BMC transplants through multiple routes. BMCs can promote the growth of blood vessels and, therefore, represent an alternative therapy," said Dr. Silva. Following primary trauma to the adult spinal cord there is evidence of haemorrhage and blood flow is attenuated, he said.
They revealed that the patients were followed for two years using MRI imaging to assess morphological changes in the spinal cord. "It is important to note that all of our patients with acute injuries improved significantly with no signs of deterioration or impediment of presumed spontaneous recovery," concluded Dr. Silva.
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